New research suggests that people who stop using new slimming jabs like semaglutide or tirzepatide may regain lost weight far faster than those who end conventional lifestyle regimens.
Published data in a prominent medical journal demonstrates that while overweight people can lose about a fifth of their body weight while undergoing treatment, the mass comes back at an average rate of 0.8 kg per month upon discontinuation.
"Individuals purchasing these drugs must be cognizant of the potential of quick weight regain when the therapy concludes," warns researcher Dr. Susan Jebb.
This pace of regain implies a return to starting weight in about one and a half years.
Comparing Therapies
The research, which reviewed dozens of studies involving thousands of participants, compared the outcomes of these new drugs with conventional dieting.
Scientists note that people who shed pounds through lifestyle changes alone typically experience a more gradual creep back—around 0.1 kg a month—post-intervention.
Explaining the Quick Regain
Experts suggest the mode of action of the injections is key to understanding the heightened rebound.
The injections copy a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Sustained high doses of GLP-1 levels far above than normal might result in the system to produce less of its endogenous hormone, and could diminish responsiveness to its actions," noted Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this GLP-1 'fix' results in hunger is no longer kept in check, making overeating much more probable."
An Ongoing Issue?
The NHS recommend the jabs for individuals with weight-linked medical conditions, accompanied by prescribed lifestyle changes.
Professionals argue that, considering the significant potential of weight regain, the therapy should be considered ongoing.
This view is reinforced by pharmaceutical companies, who state that the results "emphasize the long-term nature of excess weight," akin to managing conditions like high blood pressure.
User Testimonies
Individuals who have stopped the medication describe a sudden return of cravings.
"It was like something that goes on and I was suddenly ravenous," said an individual.
This challenge is worsened if individuals have not adopted permanent dietary or behavioural changes during treatment.
Growing Use
Figures suggest that millions of adults in the UK have tried these injections in the last 12 months, with interest being substantial.
- Use is higher among women than men.
- The middle-aged demographic shows the greatest usage rates.
- Many access the drugs through private prescriptions rather than public health services.
In conclusion, experts caution that while these medications are powerful agents for weight loss, they are not a permanent solution and long-term success hinges on integrated lifestyle support.
